A complete, photo-protecting moisturizer for daily defense against incidental UVA/UVB exposure. Protect and reduce the visible signs of photoaging with booster supplies of antioxidants, a light-activated DNA Repair enzyme, photolysome, and emollients. When used with other sun protection measures, Smart Moisture [Broad Spectrum SPF 30] decreases the risk of skin cancer and early skin aging caused by the sun.
- Provides broad spectrum UVA/UVB protection for incidental sun
- All day hydration protects essential skin barrier function
- Daily repair of the visible signs of photoaging with booster supplies of antioxidants, a light-activated
- DNA Repair enzymes and emollients.
- Dermatologist tested.
Apply liberally to face and neck in the morning.
Copper Peptide Complex®. Also known as Bis (Tripeptide-1) Copper Acetate, a delivery system that uses the body’s natural protective carrier to deliver copper peptides, an essential micronutrient for skin health, for maximum restorative benefit.
Photolysomes. The liposome encapsulated DNA repair enzyme, photolyase derived from plankton, is hyper-efficient and unique in its ability to reduce the visible signs of UV-induced damage.
Avobenzone, Homosalate, Octisalate, Octocrylene. Provides broad spectrum UV protection.
Dimethicone. Protects skin from environmental damage while retaining moisture.
Squalane. Light, fast-absorbing emollient oil hydrates and soothes dry skin.
Full Ingredient List
ACTIVE INGREDIENTS: Avobenzone 3%, Homosalate 7%, Octisalate 5%, Octocrylene, 6%.
INACTIVE INGREDIENTS: Water (Aqua), Isododecane, Hydrogenated Polydecene, Glycerin, Glyceryl Stearate, Arachidyl Alcohol, Behenyl Alcohol, Bis (Tripeptide-1) Copper Acetate, Plankton Extract, Triticum Vulgare (Wheat) Gluten Extract, Glycine Soja (Soybean) Seed Extract, Dimethicone, Arachidyl Glucoside, Caprylyl Glycol, Xanthan Gum, Cetyl Alcohol, PEG-100 Stearate, Prunus Armeniaca (Apricot) Kernel Oil, Squalane, Ammonium Acrylate/Acrylamide Copolymer, Polyisobutene, Polysorbate 20, Sodium Hydroxide, Lecithin, Sodium Chloride, Phenoxyethanol, Sorbic Acid. May Contain +/- Ultramarines.
MOLECULAR MEDICINE REPORTS 5: 570-574, 2012
Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to Skin Cancer Prevention
ENZO BERARDESCA1, MARCO BERTONA2, KARMELA ALTABAS3, VELIMIR ALTABAS3 and ENZO EMANUELE2
1San Gallicano Dermatological Institute, IRCCS, Rome; 2Department of Health Sciences, University of Pavia, Pavia, Italy; 3Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
STUDY OBJECTIVE Exposure of human skin to ultraviolet radiation (UVR) results in the formation of DNA damage that give rise to photoaging, mutations, cell death and the onset of carcinogenic (cancerous) events. Photolyase is a DNA repair enzyme that reverses damage caused by exposure to UVR. The study sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of destructive proteins and UVR-induced cell death in human skin.
STUDY DESIGN Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated UVR at a three times minimal irritation dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials -- sunscreen alone, and sunscreen plus photolyase -- were applied topically to three different sites. One additional site was left untreated and one received exposure only. Biopsy specimens were taken 72 hours after the last irradiation and measured.
STUDY SIGNIFICANCE The data from this study suggest that the addition of photolyase to a traditional Sunscreen significantly improves the protection offered by topical creams against both UVR-induced DNA damage and cell death in the skin. Notably, the human model used in this study consisted of repeated UVR exposure. As the accumulation of residual DNA damage via repeated UVR exposure is deemed to play a key role in the development of skin cancer, the results clearly indicate that photolyase-containing topical preparations are superior to traditional sunscreens in reducing cancerous and pre-cancerous skin lesions as well as photoaging.
RESULTS & CONCLUSIONS The results not only confirm, but also substantially expand previous findings on the potential usefulness of photolyase for human photoprotection. It is known that the Photolyase plus sunscreen was superior to sunscreen alone. In conclusion, the addition of photolyase to a traditional sunscreen contributes significantly to the prevention of UVR-induced DNA damage and cell death when applied topically to human skin.