DNA Damage Control Everyday Broad Spectrum SPF 44 NEOVA
DNA Damage Control Everyday Broad Spectrum SPF 44 NEOVA
DNA Damage Control Everyday Broad Spectrum SPF 44
 

DNA Damage Control Everyday Broad Spectrum SPF 44

For The Face & Body

2.5 fl. oz
$45.00

Elegant and moisturizing, EVERYDAY provides complete photoprotection in one advanced formula. Breakthrough DNA repair technology mobilizes high performance activity to reduce visible signs of the aging and burning effects of UVA and UVB rays, while light-activated photolysome helps minimize the tell-tale signs of photodamage. When used with other sun protection measures, DNA Damage Control [EVERYDAY| Broad Spectrum SPF 44] decreases the risk of skin cancer and early skin aging caused by the sun. Appropriate for all skin types.

  • Defends against broad spectrum UVA/UVB rays.
  • Restricts the appearance of sun-inflicted DNA damage.
  • Provides hyper antioxidant defense.
  • Delivers oil-free hydration 
Directions

Apply every morning to face, neck and décolletage. Apply liberally 15 minutes before sun exposure. Re-apply at least every 2 hours Warnings: For external use only. Avoid direct contract with the eyes. Stop use and seek medical attention if rash or irritation develops. Keep out of reach of children. If swallowed, contact a Poison Control Center immediately or seek medical help right away.

Ingredients

Key Performance Ingredients

Endosomes: A liposome encapsulated extract from the marine microbe, Micrococcus Lysate. Extremely UV resistant, the extract contains the enzyme UV-endonuclease which improves the appearance of sun damaged skin.
Photolysomes: The liposome encapsulated DNA repair enzyme, photolyase derived from plankton, is hyper-efficient and unique in its ability to reduce the visible signs of UV-induced insults.
L’ergothioneine: A powerful antioxidant that fights oxidative damage caused by free radical activity.
Sodium Hyaluronate: A super humectant that deeply hydrates and binds up to 1,000 times its own weight in moisture, providing an immediate moisturizing boost.
Tocopheryl Acetate (Vitamin E): A natural antioxidant and moisturizer, reducing transdermal water loss and helping to maintain optimal moisture levels.
Ascorbyl Palmitate (Vitamin C): An effective free radical-scavenging antioxidant.

Full Ingredients

ACTIVE INGREDIENTS: Octinoxate 6.5%, Octisalate 2.5%, Zinc Oxide 8.5%. INACTIVE INGREDIENTS: Allantoin, Ascorbyl Palmitate, Butylene Glycol, Cetearyl Glucoside, Citric Acid, Cyclopentasiloxane, Dimethicone, Micrococcus Lysate, Plankton Extract, Ergothioneine, Ethyl Hexyl Isononanoate,Glycereth-26, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Iodopropynyl Butylcarbamate, Isopropyl Palmitate, Lecithin, Octyl Stearate, Oleth-3 Phosphate, Panthenol, PEG-7 Trimethylolpropane Coconut Ether, Phenoxyethanol, Polyether-1, Polyisobutene, Purified Water, Retinyl Palmitate, Sodium Hyaluronate, Sodium Hydroxide, Tocopheryl Acetate, Triethoxycaprylylsilane.

Clinical Studies

MOLECULAR MEDICINE REPORTS 5: 570-574, 2012

Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to Skin Cancer Prevention

ENZO BERARDESCA1, MARCO BERTONA2, KARMELA ALTABAS3, VELIMIR ALTABASand ENZO EMANUELE2

1San Gallicano Dermatological Institute, IRCCS, Rome; 2Department of Health Sciences, University of Pavia, Pavia, Italy; 3Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia

DOI: 10.3892/mmr.2011.673

STUDY OBJECTIVE   Exposure of human skin to ultraviolet radia­tion (UVR) results in the formation of DNA damage that give rise to photoaging, mutations, cell death and the onset of carcinogenic (cancerous) events. Photolyase is a DNA repair enzyme that reverses damage caused by exposure to UVR. The study sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of destructive proteins and UVR-induced cell death in human skin.

STUDY DESIGN   Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated UVR at a three times minimal irritation dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials -- sunscreen alone, and sunscreen plus photolyase -- were applied topically to three different sites. One additional site was left untreated and one received exposure only. Biopsy specimens were taken 72 hours after the last irradiation and measured.

STUDY SIGNIFICANCE   The data from this study suggest that the addition of photolyase to a traditional Sunscreen significantly improves the protec­tion offered by topical creams against both UVR-induced DNA damage and cell death in the skin. Notably, the human model used in this study consisted of repeated UVR exposure. As the accumulation of residual DNA damage via repeated UVR exposure is deemed to play a key role in the development of skin cancer, the results clearly indicate that photolyase-containing topical preparations are superior to traditional sunscreens in reducing cancerous and pre-cancerous skin lesions as well as photoaging.

RESULTS & CONCLUSIONS    The results not only confirm, but also substantially expand previous findings on the potential usefulness of photolyase for human photoprotection.  It is known that the Photolyase plus sunscreen was superior to sunscreen alone. In conclusion, the addition of photolyase to a traditional sunscreen contributes significantly to the prevention of UVR-induced DNA damage and cell death when applied topi­cally to human skin.