Provide highly effective, broad spectrum protection for the outdoor enthusiast. Breakthrough DNA repair technology mobilizes high performance activity to reduce visible signs of aging and the burning from UVA and UVB rays, while light-activated enzymes help minimize the tell-tale signs of photodamage. When used with other sun protection measures, DNA Damage Control ACTIVE [Broad Spectrum SPF 43] decreases the risk of skin cancer and early skin aging caused by the sun. Re-apply at least every 2 hours or after 80 minutes of swimming or sweating. Appropriate for all skin types.
- Defends against broad spectrum UVA/UVB
- Restricts the appearance of sun-inflicted DNA damage
- Provides hyper antioxidant defense.
- Water-resistant [80 minutes]
Apply every morning to face, neck and back of hands. Apply liberally 15 minutes before sun exposure. Re-apply at least every 2 hours or after 80 minutes of swimming or sweating.
Key Performance Ingredients
Endosomes. A liposome encapsulated extract from the marine microbe, Micrococcus Lysate. Extremely UV resistant, the extract contains the enzyme UVendonuclease which improves the appearance of sun-damaged skin.
L’ergothioneine. An intense antioxidant that powerfully fights oxidative damage.
Photolysomes. The liposome encapsulated DNA repair enzyme, photolyase derived from plankton, is hyper-efficient and unique in its ability to reduce the visible signs of UV-induced insults.
Ascorbyl Palmitate [Vitamin C]. An effective free radical-scavenging antioxidant.
Active Ingredients: Octinoxate 7.5%, Zinc Oxide 9.0%.
Inactive Ingredients: Ascorbyl Palmitate, Butylene Glycol, Citric Acid, Cyclopentasiloxane, Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Dimethicone/Vinyldimethicone Crosspolymer, Ergothioneine, Ethyl Hexyl Isononanoate, Iodopropynyl Butylcarbamate, Lauryl PEG-9 Polymethylsiloxyethyl Dimethicone, Lecithin, Micrococcus Lysate, Phenoxyethanol, Plankton Extract, Purified Water, Retinyl Palmitate, Sodium Chloride, Sodium Hydroxide, Triethoxycaprylylsilane.
MOLECULAR MEDICINE REPORTS 5: 570-574, 2012
Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to Skin Cancer Prevention
ENZO BERARDESCA1, MARCO BERTONA2, KARMELA ALTABAS3, VELIMIR ALTABAS3 and ENZO EMANUELE2
1San Gallicano Dermatological Institute, IRCCS, Rome; 2Department of Health Sciences, University of Pavia, Pavia, Italy; 3Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
STUDY OBJECTIVE Exposure of human skin to ultraviolet radiation (UVR) results in the formation of DNA damage that give rise to photoaging, mutations, cell death and the onset of carcinogenic (cancerous) events. Photolyase is a DNA repair enzyme that reverses damage caused by exposure to UVR. The study sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of destructive proteins and UVR-induced cell death in human skin.
STUDY DESIGN Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated UVR at a three times minimal irritation dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials -- sunscreen alone, and sunscreen plus photolyase -- were applied topically to three different sites. One additional site was left untreated and one received exposure only. Biopsy specimens were taken 72 hours after the last irradiation and measured.
STUDY SIGNIFICANCE The data from this study suggest that the addition of photolyase to a traditional Sunscreen significantly improves the protection offered by topical creams against both UVR-induced DNA damage and cell death in the skin. Notably, the human model used in this study consisted of repeated UVR exposure. As the accumulation of residual DNA damage via repeated UVR exposure is deemed to play a key role in the development of skin cancer, the results clearly indicate that photolyase-containing topical preparations are superior to traditional sunscreens in reducing cancerous and pre-cancerous skin lesions as well as photoaging.
RESULTS & CONCLUSIONS The results not only confirm, but also substantially expand previous findings on the potential usefulness of photolyase for human photoprotection. It is known that the Photolyase plus sunscreen was superior to sunscreen alone. In conclusion, the addition of photolyase to a traditional sunscreen contributes significantly to the prevention of UVR-induced DNA damage and cell death when applied topically to human skin.