Sheer but significant photoprotection with two DNA repair enzymes, two physical screening agents, two light-diffusing factors and EGT, a hyper-antioxidant for complete protection and luminosity. Its universal tint provides a photo finish and makes it perfect if worn alone or as an under-makeup primer. All that + Fragrance and Oil-Free and Highly Water Resistant to 80 minutes. When used with other sun protection measures, DNA Damage Control [SILC SHEER 2.0 | Broad Spectrum SPF 40] decreases the risk of skin cancer and early skin aging caused by the sun. Appropriate for all skin types.
- Offers superior protection
- Defends against broad spectrum UVA/UVB rays.
- Restricts the appearance of sun-inflicted damage
- Color Correction cream illuminates and brightens with a tinted, pearl finish.
- Water Resistant [80 minutes]
Recommended for all skin types, even the most sensitive.
Apply liberally every morning to face, neck and back of hands 15 minutes before sun exposure. Re-apply at least every 2 hours or after 80 minutes of swimming or sweating. Warnings: For external use only. Avoid direct contract with the eyes. Stop use and seek medical attention if rash or irritation develops. Keep out of reach of children. If swallowed, contact a Poison Control Center immediately or seek medical help right away.
Key Performance Ingredients
Alumina, Butylene Glycol, Citric Acid, Plankton Extract, Cyclopentasiloxane, Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Ergothioneine, HDI/Trimethylol Hexyllactone Crosspolymer, Iodopropynyl Butylcarbamate, Iron Oxides, Lauryl PEG-9 Polymethylsiloxyethyl Dimethicone, Lecithin, Methicone, Micrococcus Lysate, Octyldodecyl Neopentanoate,Phenoxyethanol, Purified Water, Silica, Sodium Chloride, Sodium Hydroxide, Triethoxycaprylylsilane.
MOLECULAR MEDICINE REPORTS 5: 570-574, 2012
Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to Skin Cancer Prevention
ENZO BERARDESCA1, MARCO BERTONA2, KARMELA ALTABAS3, VELIMIR ALTABAS3 and ENZO EMANUELE2
1San Gallicano Dermatological Institute, IRCCS, Rome; 2Department of Health Sciences, University of Pavia, Pavia, Italy; 3Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
STUDY OBJECTIVE Exposure of human skin to ultraviolet radiation (UVR) results in the formation of DNA damage that give rise to photoaging, mutations, cell death and the onset of carcinogenic (cancerous) events. Photolyase is a DNA repair enzyme that reverses damage caused by exposure to UVR. The study sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of destructive proteins and UVR-induced cell death in human skin.
STUDY DESIGN Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated UVR at a three times minimal irritation dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials -- sunscreen alone, and sunscreen plus photolyase -- were applied topically to three different sites. One additional site was left untreated and one received exposure only. Biopsy specimens were taken 72 hours after the last irradiation and measured.
STUDY SIGNIFICANCE The data from this study suggest that the addition of photolyase to a traditional Sunscreen significantly improves the protection offered by topical creams against both UVR-induced DNA damage and cell death in the skin. Notably, the human model used in this study consisted of repeated UVR exposure. As the accumulation of residual DNA damage via repeated UVR exposure is deemed to play a key role in the development of skin cancer, the results clearly indicate that photolyase-containing topical preparations are superior to traditional sunscreens in reducing cancerous and pre-cancerous skin lesions as well as photoaging.
RESULTS & CONCLUSIONS The results not only confirm, but also substantially expand previous findings on the potential usefulness of photolyase for human photoprotection. It is known that the Photolyase plus sunscreen was superior to sunscreen alone. In conclusion, the addition of photolyase to a traditional sunscreen contributes significantly to the prevention of UVR-induced DNA damage and cell death when applied topically to human skin.